Granulocyte colony-stimulating factor-producing lung cancer and acute respiratory distress syndrome

Clin Respir J. 2015 Apr;9(2):250-2. doi: 10.1111/crj.12111. Epub 2014 Feb 24.

Abstract

Granulocyte colony-stimulating factor (G-CSF)-producing lung cancers are known to cause extreme leukocytosis. However, acute respiratory distress syndrome (ARDS) caused by G-CSF-producing lung cancer is extremely rare. We present a case of G-CSF-producing lung cancer with marked leukocytosis, which rapidly led to severe ARDS after the patient developed pneumonia. The present case suggests that extreme leukocytosis may easily lead to ARDS, triggered by infection. Thus, G-CSF-producing lung cancer with marked leukocytosis should be carefully monitored before surgery and during treatment.

Keywords: ARDS; G-CSF; large-cell carcinoma; leukocytosis; lung cancer.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma / diagnosis
  • Carcinoma / etiology*
  • Fatal Outcome
  • Granulocyte Colony-Stimulating Factor / physiology*
  • Humans
  • Leukocytosis / diagnosis
  • Leukocytosis / etiology*
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / etiology*
  • Male
  • Middle Aged
  • Respiratory Distress Syndrome / diagnosis
  • Respiratory Distress Syndrome / etiology*

Substances

  • Granulocyte Colony-Stimulating Factor