Many biotic and abiotic stresses can cause oxidative stress in plants. The identification of components involved in plant response to oxidative stress has attracted wide attention. The members of AtSRO family, including AtRCD1, AtSRO1, and AtSRO5, regulate plants' response to oxidative stress. AtSROs participate in plant normal growth and development, and play important roles in plant response to stresses, such as drought, salt, heavy metal, and so on. In addition, AtSROs possess some special domains, including PARP and RST. It is speculated that AtSROs may function in regulating protein transcription, adjustment, and modification. This review highlights some recent progresses, such as basic situation of AtSROs, effects of AtSRO family proteins on plant growth and response to abiotic stress, which will provide a theoretical basis for further studying on biological functions of AtSRO.