Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG)

J Neuroimmunol. 1987 Dec;17(1):61-9. doi: 10.1016/0165-5728(87)90031-2.

Abstract

Antibody responses to the myelin/oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) were determined in the sera of Hartley guinea pigs with chronic relapsing experimental allergic encephalomyelitis (CREAE) using an enzyme-linked immunoassay. The sera were also tested for in vivo demyelinating activity by infusion into the subarachnoid space of normal rats. In contrast to the MBP titres, the anti-MOG antibody titres showed good correlation with the in vivo demyelinating activity of the sera (r = 0.91, P less than 0.001). This result suggests that antibodies directed against MOG may be involved in the pathogenesis of demyelination in CREAE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoantibodies / analysis*
  • Chronic Disease
  • Demyelinating Diseases / etiology*
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Glycoproteins / immunology*
  • Guinea Pigs
  • Humans
  • Myelin Basic Protein / immunology
  • Myelin Proteins / immunology*
  • Neuroglia / immunology*
  • Oligodendroglia / immunology*

Substances

  • Autoantibodies
  • Glycoproteins
  • Myelin Basic Protein
  • Myelin Proteins