Significance of higher-order chromatin architecture for neuronal function and dysfunction

Neuropharmacology. 2014 May:80:28-33. doi: 10.1016/j.neuropharm.2014.01.016. Epub 2014 Jan 20.

Abstract

Recent studies in neurons indicate that the large-scale chromatin architectural framework, including chromosome territories or lamina-associated chromatin, undergoes dynamic changes that represent an emergent level of regulation of neuronal gene-expression. This phenomenon has been implicated in neuronal differentiation, long-term potentiation, seizures, and disorders of neural plasticity such as Rett syndrome and epilepsy.

Keywords: Cell nucleus; Chromatin; Chromosome territory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / cytology
  • Brain / metabolism*
  • Brain / pathology
  • Chromatin Assembly and Disassembly*
  • Epigenesis, Genetic*
  • Epilepsy / metabolism
  • Epilepsy / pathology
  • Gene Expression Regulation*
  • Humans
  • Long-Term Potentiation
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Nervous System Diseases / metabolism*
  • Nervous System Diseases / pathology
  • Neurogenesis
  • Neurons / cytology
  • Neurons / metabolism*
  • Neurons / pathology
  • Nuclear Lamina / metabolism
  • Nuclear Lamina / pathology
  • Rett Syndrome / metabolism
  • Rett Syndrome / pathology

Substances

  • Nerve Tissue Proteins