Abstract
Recent studies in neurons indicate that the large-scale chromatin architectural framework, including chromosome territories or lamina-associated chromatin, undergoes dynamic changes that represent an emergent level of regulation of neuronal gene-expression. This phenomenon has been implicated in neuronal differentiation, long-term potentiation, seizures, and disorders of neural plasticity such as Rett syndrome and epilepsy.
Keywords:
Cell nucleus; Chromatin; Chromosome territory.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Brain / cytology
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Brain / metabolism*
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Brain / pathology
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Chromatin Assembly and Disassembly*
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Epigenesis, Genetic*
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Epilepsy / metabolism
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Epilepsy / pathology
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Gene Expression Regulation*
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Humans
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Long-Term Potentiation
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism*
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Nervous System Diseases / metabolism*
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Nervous System Diseases / pathology
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Neurogenesis
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Neurons / cytology
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Neurons / metabolism*
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Neurons / pathology
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Nuclear Lamina / metabolism
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Nuclear Lamina / pathology
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Rett Syndrome / metabolism
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Rett Syndrome / pathology