Cinchona alkaloids from Cinchona succirubra and Cinchona ledgeriana

Planta Med. 2014 Feb;80(2-3):223-30. doi: 10.1055/s-0033-1360279. Epub 2014 Jan 22.

Abstract

Seven new cinchona alkaloids, cinchonanines A-G (1-7), and 29 known alkaloids were isolated from the barks of Cinchona surrirubra and C. ledgeriana collected from Yunnan Province in China. The new structures were elucidated by extensive spectroscopic analysis. All compounds were evaluated for their cytotoxicity against five human cancer cell lines. Compounds 2, 13, 14, and 15 showed moderate cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cinchona / chemistry*
  • Cinchona Alkaloids / chemistry
  • Cinchona Alkaloids / isolation & purification
  • Cinchona Alkaloids / pharmacology*
  • Cytotoxins / chemistry
  • Cytotoxins / isolation & purification
  • Cytotoxins / pharmacology*
  • Humans
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Cinchona Alkaloids
  • Cytotoxins