[Evaluation of a long-term sensomotor deficit after neonatal rat brain ischemia/hypoxia]

Zh Vyssh Nerv Deiat Im I P Pavlova. 2013 May-Jun;63(3):405-16. doi: 10.7868/s0044467713030131.
[Article in Russian]

Abstract

The application of magnetic resonance imaging method showed that ischemia/hypoxia of the brain of neonatal rats made by the protocol suggested by Levine-Rice induces one-sided lesions in the areas of cerebral cortex, striatum and hippocampus. Unilateral ischemic injury leads to a long-term sensorimotor and behavioral distortions within 90-115 days after the operation which has been tested in animals by the battery of tests including Cylinder, Beam-walking, Staircase and Limb-placing test. Chosen battery of tests in combination with magnetic resonance imaging allows to reliably estimate the long-term sensorimotor recovery in adult animals suffered an injury in neonatal age.

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Animals, Newborn*
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / injuries
  • Corpus Striatum / pathology
  • Feedback, Sensory
  • Hippocampus / drug effects
  • Hippocampus / pathology
  • Humans
  • Hypoxia-Ischemia, Brain / pathology*
  • Magnetic Resonance Imaging
  • Male
  • Rats