Abstract
A new trehalose analog, lentztrehalose [4-O-(2,3-dihydroxy-3-methylbutyl)trehalose], was isolated from an actinomycete Lentzea sp. Lentztrehalose is only weakly hydrolyzed by the trehalose-hydrolyzing enzyme, trehalase, so can be regarded as an enzyme-stable analog of trehalose. Although lentztrehalose does not show apparent toxicity to mammalian cells and microbes, it has antitumor activity in mice bearing S-180 sarcoma and Ehrlich carcinoma cells. In ovariectomized mice, lentztrehalose displayed a bone reinforcement effect in the femur that was superior to trehalose and induced non-morbid suppression of weight gain comparable with trehalose. These results indicate that enzyme-stable analogs of trehalose, such as lentztrehalose, may be more beneficial for human health and thus have potential as substitutes for trehalose as a sweetener.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Actinobacteria / growth & development
-
Actinobacteria / metabolism*
-
Actinobacteria / ultrastructure
-
Animals
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification
-
Antineoplastic Agents / metabolism
-
Antineoplastic Agents / therapeutic use*
-
Bone Density Conservation Agents / chemistry
-
Bone Density Conservation Agents / isolation & purification
-
Bone Density Conservation Agents / metabolism
-
Bone Density Conservation Agents / therapeutic use*
-
Carcinoma, Ehrlich Tumor / drug therapy*
-
Carcinoma, Ehrlich Tumor / pathology
-
Disease Models, Animal
-
Dose-Response Relationship, Drug
-
Drug Discovery*
-
Female
-
Humans
-
Mice
-
Mice, Inbred ICR
-
Molecular Structure
-
Non-Nutritive Sweeteners / chemistry
-
Non-Nutritive Sweeteners / isolation & purification
-
Non-Nutritive Sweeteners / metabolism
-
Non-Nutritive Sweeteners / therapeutic use
-
Osteoporosis, Postmenopausal / prevention & control*
-
Sarcoma 180 / drug therapy*
-
Sarcoma 180 / pathology
-
Substrate Specificity
-
Survival Analysis
-
Trehalase / metabolism
-
Trehalose / analogs & derivatives*
-
Trehalose / chemistry
-
Trehalose / isolation & purification
-
Trehalose / metabolism
-
Trehalose / therapeutic use
-
Tumor Burden / drug effects
-
Weight Gain / drug effects
Substances
-
4-O-(2,3-dihydroxy-3-methylbutyl)trehalose
-
Antineoplastic Agents
-
Bone Density Conservation Agents
-
Non-Nutritive Sweeteners
-
Trehalose
-
Trehalase