Direct access to isoindolines through tandem Rh(III)-catalyzed alkenylation and cyclization of N-benzyltriflamides

Chem Commun (Camb). 2014 Mar 4;50(18):2350-2. doi: 10.1039/c3cc49486a. Epub 2014 Jan 21.

Abstract

The rhodium-catalyzed oxidative alkenylation of N-benzyltriflamides with olefins followed by an intramolecular cyclization via C-H bond activation is described. This method results in the direct and efficient synthesis of highly substituted isoindoline frameworks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzylamines / chemistry*
  • Catalysis
  • Cyclization
  • Isoindoles / chemical synthesis*
  • Isoindoles / chemistry
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Rhodium / chemistry*
  • Sulfonamides / chemistry*

Substances

  • Benzylamines
  • Isoindoles
  • Organometallic Compounds
  • Sulfonamides
  • Rhodium