Two new secondary metabolites from Xylaria sp. cfcc 87468

Molecules. 2014 Jan 20;19(1):1250-7. doi: 10.3390/molecules19011250.

Abstract

A new isocoumarin glycoside, 3R-(+)-5-O-[6'-O-acetyl]-α-D-glucopyranosyl-5-hydroxymellein (1), and a new phenylethanol glycoside, (-)-phenylethyl-8-O-α-L-rhamno-pyranoside (2), were isolated from the ethyl acetate extract of the fungus Xylaria sp. cfcc 87468, together with five known steroids, β-sitosterol (3), stigmast-4-en-3-one (4), ergosterol (5), (22E)-cholesta-4,6,8(14),22-tetraen-3-one (6), and 4α-methyl- ergosta-8(14),24(28)-dien-3β-ol (7). The structures of compounds 1 and 2 were elucidated by MS, extensive 1D and 2D NMR spectroscopy, and the circular dichroism (CD) spectroscopy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Circular Dichroism
  • Isocoumarins / chemistry*
  • Isocoumarins / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Molecular Motor Proteins
  • Monosaccharides / chemistry*
  • Monosaccharides / isolation & purification
  • Steroids / chemistry
  • Steroids / isolation & purification
  • Xylariales / chemistry*

Substances

  • 5-O-(6'-O-acetyl)-alpha-D-glucopyranosyl-5-hydroxymellein
  • Isocoumarins
  • Molecular Motor Proteins
  • Monosaccharides
  • Steroids
  • phenylethyl-8-O-alpha-L-rhamnopyranoside