Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Lin-Chiang Sherlock Huang; Wen-Yuan Hsieh; Jiun-Yu Chen; Su-Chin Huang; Jen-Kun Chen; Ming-Hua Hsu

doi:10.1016/j.apradiso.2013.12.025

Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Appl Radiat Isot. 2014 Jun:88:89-93. doi: 10.1016/j.apradiso.2013.12.025. Epub 2013 Dec 27.

Authors

Lin-Chiang Sherlock Huang¹, Wen-Yuan Hsieh², Jiun-Yu Chen³, Su-Chin Huang³, Jen-Kun Chen³, Ming-Hua Hsu⁴

Affiliations

¹ Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC; Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC.
² Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu 31040, Taiwan, ROC.
³ Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan, ROC.
⁴ Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC. Electronic address: mhhsu@mx.nthu.edu.tw.

PMID: 24447933
DOI: 10.1016/j.apradiso.2013.12.025

Abstract

We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.

Keywords: BNCT; Drug delivery; Micelle; PEOz; PLA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absorbable Implants
Boron Compounds / administration & dosage
Boron Compounds / chemistry*
Boron Compounds / toxicity*
Boron Neutron Capture Therapy / methods*
Cell Survival / drug effects*
Delayed-Action Preparations / administration & dosage
Delayed-Action Preparations / chemical synthesis*
Delayed-Action Preparations / toxicity
Diffusion
Drug Design
HeLa Cells
Humans
Lactic Acid / analogs & derivatives*
Lactic Acid / chemistry
Lactic Acid / toxicity
Polymers / chemistry*
Polymers / toxicity*

Substances

2,2'-bis(2-oxazoline) linked poly(lactic acid)
4,4,5,5-tetramethyl(1,3,2)dioxaborolane
Boron Compounds
Delayed-Action Preparations
Polymers
Lactic Acid