The roles of Pellino E3 ubiquitin ligases in immunity

Paul N Moynagh

doi:10.1038/nri3599

The roles of Pellino E3 ubiquitin ligases in immunity

Nat Rev Immunol. 2014 Feb;14(2):122-31. doi: 10.1038/nri3599. Epub 2014 Jan 21.

Author

Paul N Moynagh¹

Affiliation

¹ 1] Institute of Immunology, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland. [2] Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast BT9 7AE, Northern Ireland, United Kingdom.

PMID: 24445667
DOI: 10.1038/nri3599

Abstract

Pellino proteins were initially characterized as a family of E3 ubiquitin ligases that can catalyse the ubiquitylation of interleukin-1 receptor-associated kinase 1 (IRAK1) and regulate innate immune signalling pathways. More recently, physiological and molecular roles for members of the Pellino family have been described in the regulation of innate and adaptive immune responses by ubiquitylation. This Review describes the emerging roles of Pellino proteins in innate and adaptive immunity and discusses the mechanistic basis of these functions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Immunity, Innate
Nod2 Signaling Adaptor Protein / physiology
Nuclear Proteins / chemistry
Nuclear Proteins / physiology*
Protein Processing, Post-Translational
Signal Transduction
Toll-Like Receptors / physiology
Ubiquitin-Protein Ligases / chemistry
Ubiquitin-Protein Ligases / physiology*

Substances

NOD2 protein, human
Nod2 Signaling Adaptor Protein
Nuclear Proteins
Peli2 protein, mouse
Toll-Like Receptors
PELI1 protein, human
PELI3 protein, human
Ubiquitin-Protein Ligases