A new sesquilignan glucoside from Uraria sinensis

Molecules. 2014 Jan 17;19(1):1178-88. doi: 10.3390/molecules19011178.

Abstract

A new sesquilignan glucoside, urariasinoside A (1), together with eight known compounds, including two lignans, a sesquilignan, a dilignan, and four flavonoid derivatives were isolated from the aerial parts of Uraria sinensis. Their structures were determined on the basis of extensive spectroscopic analyses and comparison with literature data. Compound 1 was evaluated for in vitro cytotoxicity activity against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Fabaceae / chemistry*
  • Glucosides / chemistry*
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • HL-60 Cells
  • Humans
  • Lignans / chemistry*
  • Lignans / isolation & purification
  • Lignans / pharmacology
  • MCF-7 Cells
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Plant Components, Aerial / chemistry*
  • Plant Extracts / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Glucosides
  • Lignans
  • Plant Extracts