Discovery of novel diterpenoids from Sinularia arborea

Kuan-Hua Chen; Chang-Feng Dai; Tsong-Long Hwang; Chun-Yu Chen; Jan-Jung Li; Jih-Jung Chen; Yang-Chang Wu; Jyh-Horng Sheu; Wei-Hsien Wang; Ping-Jyun Sung

doi:10.3390/md12010385

Discovery of novel diterpenoids from Sinularia arborea

Mar Drugs. 2014 Jan 17;12(1):385-93. doi: 10.3390/md12010385.

Authors

Affiliations

¹ Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. asdfgh0213@gmail.com.
² Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. corallab@ntu.edu.tw.
³ Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. htl@mail.cgu.edu.tw.
⁴ Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. rainywoo2000@yahoo.com.tw.
⁵ Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. jj@nmmba.gov.tw.
⁶ Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. jjchen@mail.tajen.edu.tw.
⁷ Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. yachwu@mail.cmu.edu.tw.
⁸ Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. sheu@mail.nsysu.edu.tw.
⁹ Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. whw@nmmba.gov.tw.
¹⁰ Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.

Abstract

Two novel diterpenoids, sinularbols A (1) and B (2), which were found to possess a new carbon skeleton were isolated from the soft coral Sinularia arborea. The structures of compounds 1 and 2 were elucidated by spectroscopic methods and 2 displayed a moderately inhibitory effect on the generation of superoxide anion by human neutrophils.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Superoxides / chemistry

Substances

Diterpenes
Superoxides