Early endoscopic dilation and mitomycin application in the treatment of acquired tracheal stenosis

Eur J Pediatr Surg. 2014 Feb;24(1):39-45. doi: 10.1055/s-0033-1357754. Epub 2014 Jan 17.

Abstract

Introduction: Acquired airway stenosis is a common complication in children after periods of tracheal intubation. We reviewed our experience in the endoscopic treatment of these lesions.

Patients and methods: We performed a retrospective review of patients who presented acquired tracheal-subglottic stenosis (SGS) treated at our center from 2005 to 2012. We reviewed the etiology, age, clinical presentation, methods of diagnosis, number of bronchoscopies, angioplasty balloon dilations performed, and long-term results.

Results: A total of 18 patients (13 M, 5 F) were treated at our institution between 2005 and 2012. Median age at treatment was 3.5 months (range, 1-96 months). Of the 18 children, 16 children had SGS (all cases were postintubation), and 2 children presented tracheal stenosis (1 postintubation, 1 after tracheal surgery). Median intubation time was 30 days (range, 3-120 days). Extubation failure and stridor were the main clinical features. SGS were diagnosed as grade I in three patients, grade II in nine patients, and grade III in six patients. Bronchoscopy allowed diagnostic in all cases, and was followed by angioplasty balloon dilation, with a median of 2.5 (range, 1-5) sessions. In SGS grade I, the relation patient/number of dilations was 1; in SGS grade II 2.6, and in SGS grade III 3.5. Mitomycin was applied in 15 patients. No patients presented intraoperative complications or required reoperation. Median follow-up time was 36 months (range, 5-72 months) and no recurrence was noticed.

Conclusions: Early endoscopic dilation with balloon shows as an effective and safe treatment in acquired tracheal and SGS.

MeSH terms

  • Angioplasty, Balloon*
  • Bronchoscopy*
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Early Medical Intervention*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Intubation, Intratracheal / adverse effects
  • Laryngostenosis / classification
  • Laryngostenosis / diagnosis
  • Laryngostenosis / therapy*
  • Male
  • Mitomycin / administration & dosage*
  • Postoperative Complications / diagnosis
  • Postoperative Complications / therapy
  • Retreatment
  • Tracheal Stenosis / classification
  • Tracheal Stenosis / diagnosis
  • Tracheal Stenosis / therapy*

Substances

  • Mitomycin