Mesoporous bioactive glass doped-poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) composite scaffolds with 3-dimensionally hierarchical pore networks for bone regeneration

Shengbing Yang; Jing Wang; Liangji Tang; Haiyong Ao; Honglue Tan; Tingting Tang; Changsheng Liu

doi:10.1016/j.colsurfb.2013.12.052

Mesoporous bioactive glass doped-poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) composite scaffolds with 3-dimensionally hierarchical pore networks for bone regeneration

Colloids Surf B Biointerfaces. 2014 Apr 1:116:72-80. doi: 10.1016/j.colsurfb.2013.12.052. Epub 2013 Dec 30.

Authors

Shengbing Yang¹, Jing Wang², Liangji Tang³, Haiyong Ao⁴, Honglue Tan⁴, Tingting Tang⁴, Changsheng Liu⁵

Affiliations

¹ The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China; Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China; Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, PR China.
² Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China. Electronic address: wjbiomat@163.com.
³ The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China.
⁴ Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China.
⁵ The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China; Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China; Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, PR China. Electronic address: csliu@sh163.net.

PMID: 24441182
DOI: 10.1016/j.colsurfb.2013.12.052

Abstract

Scaffolds play a critical role in bone tissue engineering. Composite scaffolds made of biodegradable polymers and bioactive inorganic compounds have demonstrated superior properties in bone defect repair. In this study, highly bioactive, resorbable poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx)-based scaffolds were prepared using combinational 3-dimensional (3D) printing and surface-doping protocol. Structural and morphological characterization of the composite scaffolds demonstrated the homogenous surface-coating of mesoporous bioactive glass (MBG) throughout their porous framework. These hierarchical scaffolds showed bioactivity superior to that of scaffolds made of pure PHBHHx. MBG coating appeared to provide a better environment for human mesenchymal stem cells (hMSCs) attachment, activity, and osteogenic differentiation. Our study indicates that MBG-coated PHBHHx (PHBM) scaffolds may be excellent candidates for use in bone tissue engineering.

Keywords: Bone regeneration; Mesopore; Scaffolds; Surface modification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3-Hydroxybutyric Acid / chemistry*
Biocompatible Materials / chemical synthesis
Biocompatible Materials / chemistry*
Bone Regeneration*
Caproates / chemistry*
Ceramics / chemistry*
Humans
Mesenchymal Stem Cells / cytology
Particle Size
Porosity
Surface Properties
Tissue Engineering

Substances

Biocompatible Materials
Bioglass
Caproates
poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)
3-Hydroxybutyric Acid