Antiplasmodial and cytotoxic dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv

Ferdinand Mouafo Talontsi; Marc Lamshöft; Clovis Douanla-Meli; Simeon Fogue Kouam; Michael Spiteller

doi:10.1016/j.fitote.2014.01.003

Antiplasmodial and cytotoxic dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv

Fitoterapia. 2014 Mar:93:233-8. doi: 10.1016/j.fitote.2014.01.003. Epub 2014 Jan 17.

Authors

Ferdinand Mouafo Talontsi¹, Marc Lamshöft¹, Clovis Douanla-Meli², Simeon Fogue Kouam³, Michael Spiteller⁴

Affiliations

¹ Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
² Institute of Biology, University of Kassel, Heinrich-Plett-Strasse 40, D-34132 Kassel, Germany.
³ Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany; Department of Chemistry, Higher Teachers' Training College, University of Yaoundé I, P. O. Box 47, Yaoundé, Cameroon.
⁴ Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany. Electronic address: m.spiteller@infu.tu-dortmund.de.

PMID: 24440906
DOI: 10.1016/j.fitote.2014.01.003

Abstract

Two unusual dibenzofurans, preussiafurans A-B (1-2), together with six known compounds have been isolated from the fungus Preussia sp. occurring in Enantia chlorantha Oliv. The structures were established on the basis of 1D and 2D NMR spectroscopy and MS analysis. Compounds 1-4 showed antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum (NF54) and moderate cytotoxicity on L6 cell lines with IC50 values of 8.67 and 14.8 μM, respectively.

Keywords: Antiplasmodial activity; Cytotoxicity; Dibenzofurans; Enanthia chloranta Oliv; Endophyte; Preussia sp..

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Annonaceae / microbiology*
Antimalarials / chemistry
Antimalarials / isolation & purification*
Ascomycota / chemistry*
Ascomycota / classification
Ascomycota / metabolism
Benzofurans / chemistry
Benzofurans / isolation & purification*
Benzofurans / toxicity
Cell Line
Inhibitory Concentration 50
Molecular Structure
Rats
Secondary Metabolism

Substances

Antimalarials
Benzofurans
preussiafuran A
preussiafuran B