Inhibition of death receptor signaling by bacterial gut pathogens

Cytokine Growth Factor Rev. 2014 Apr;25(2):235-43. doi: 10.1016/j.cytogfr.2013.12.012. Epub 2013 Dec 25.

Abstract

Gastrointestinal bacterial pathogens such as enteropathogenic Escherichia coli, Salmonella and Shigella control inflammatory and apoptotic signaling in human intestinal cells to establish infection, replicate and disseminate to other hosts. These pathogens manipulate host cell signaling through the translocation of virulence effector proteins directly into the host cell cytoplasm, which then target various signaling pathways. Death receptors such as TNFR1, FAS and TRAIL-R induce signaling cascades that are crucial to the clearance of pathogens, and as such are major targets for inhibition by pathogens. This review focuses on what is known about how bacterial gut pathogens inhibit death receptor signaling to suppress inflammation and prevent apoptosis.

Keywords: Apoptosis; Bacterial pathogens; Death receptor; Inflammation; T3SS effectors.

Publication types

  • Review

MeSH terms

  • Apoptosis / immunology
  • Bacterial Secretion Systems / immunology
  • Escherichia coli / immunology
  • Gastrointestinal Tract / immunology*
  • Gastrointestinal Tract / microbiology*
  • Humans
  • Inflammation / immunology
  • Microbiota / immunology
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism
  • Receptors, Death Domain / antagonists & inhibitors*
  • Receptors, Death Domain / immunology*
  • Salmonella / immunology
  • Shigella / immunology
  • Signal Transduction / immunology

Substances

  • Bacterial Secretion Systems
  • NF-kappa B
  • Receptors, Death Domain