Bistable parvalbumin circuits pivotal for brain plasticity

Takao K Hensch

doi:10.1016/j.cell.2013.12.034

Bistable parvalbumin circuits pivotal for brain plasticity

Cell. 2014 Jan 16;156(1-2):17-9. doi: 10.1016/j.cell.2013.12.034.

Author

Takao K Hensch¹

Affiliation

¹ Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: hensch@mcb.harvard.edu.

Abstract

Experience shapes brain function throughout life to varying degrees. In a recent issue of Nature, Donato et al. identify reversible shifts in focal parvalbumin cell state during adult learning, placing it on a mechanistic continuum with developmental critical periods. A disinhibitory microcircuit controls the plasticity switch to modulate memory formation.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Hippocampus / cytology*
Hippocampus / physiology*
Interneurons / metabolism*
Learning / physiology*
Male
Neuronal Plasticity / physiology*
Parvalbumins / metabolism*

Substances

Parvalbumins

Abstract

Publication types

MeSH terms

Substances

Grants and funding