Background aims: Currently available treatment methods for advanced plasmacytoma include surgery, chemotherapy, radiotherapy, immunomodulatory agents, hematopoietic stem cell transplantation and donor lymphocyte infusion. We report a case of advanced refractory multiple solitary plasmacytomas in a 68-year-old Asian man with multiple bone lesions, in whom autologous cytokine-induced killer (CIK) cells were administered in an effort to eliminate residual tumor lesions.
Methods: CIK cells were infused monthly for 21 courses.
Results: The patient has survived 63 months since the first hospital visit without disease progression for 40 months.
Conclusions: This case represents the first report of autologous CIK cell immunotherapy used successfully to suppress multiple solitary plasmacytomas and resolve bone lesions.
Keywords: cancer; chemotherapy; cytokine-induced killer cells; immunotherapy; plasmacytoma.
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