Campylobacter coli cultured from the stools of a patient with immunoproliferative small intestinal disease

Clin Microbiol Infect. 2014 Sep;20(9):908-11. doi: 10.1111/1469-0691.12545. Epub 2014 Feb 20.

Abstract

Campylobacter has been associated with immunoproliferative small intestinal disease (IPSID), on the basis of 16S rDNA sequencing, in situ hybridization, and immunohistochemistry. Here, for the first time, we have cultured Campylobacter from the stools of a patient with IPSID. Phenotypic analysis and whole genome sequencing identified Campylobacter coli. PCR on a IPSID tissue biopsy sample was positive for Campylobacter coli and negative for Campylobacter jejuni. These findings further support a causative role for Campylobacter in the development of IPSID.

Keywords: Campylobacter; IPSID; immunoproliferative small intestinal disease; lymphoma; α-Heavy-chain disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Campylobacter coli / genetics
  • Campylobacter coli / isolation & purification*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Feces / microbiology*
  • Genome, Bacterial
  • Histocytochemistry
  • Humans
  • Immunohistochemistry
  • Immunoproliferative Small Intestinal Disease / microbiology*
  • Immunoproliferative Small Intestinal Disease / pathology
  • Male
  • Microscopy
  • Positron-Emission Tomography
  • Radiography, Abdominal
  • Sequence Analysis, DNA*

Substances

  • DNA, Bacterial