Abstract
The first synthesis of the furan-containing snyderane, (+)-luzofuran, is reported. The key step in this approach was an electrophilic brominative cyclization, which was accomplished using a nucleophilic N-heterocycle-flanked phosphoramidite catalyst in combination with the common laboratory reagent N-bromosuccinimide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bromosuccinimide / chemistry*
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Catalysis
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Cyclization
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Furans / chemical synthesis*
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Furans / chemistry*
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Indicators and Reagents / chemistry
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Molecular Structure
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Organophosphorus Compounds / chemistry*
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / chemistry
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Stereoisomerism
Substances
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Furans
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Indicators and Reagents
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Organophosphorus Compounds
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Sesquiterpenes
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ancistrofuran
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luzofuran
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phosphoramidite
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snyderane
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Bromosuccinimide
Grants and funding
National Institutes of Health, United States