Quetiapine responsive catatonia in an autistic patient with comorbid bipolar disorder and idiopathic basal ganglia calcification

Makoto Ishitobi; Masao Kawatani; Mizuki Asano; Hirotaka Kosaka; Takashi Goto; Michio Hiratani; Yuji Wada

doi:10.1016/j.braindev.2013.12.005

Quetiapine responsive catatonia in an autistic patient with comorbid bipolar disorder and idiopathic basal ganglia calcification

Brain Dev. 2014 Oct;36(9):823-5. doi: 10.1016/j.braindev.2013.12.005. Epub 2014 Jan 13.

Authors

Makoto Ishitobi¹, Masao Kawatani², Mizuki Asano³, Hirotaka Kosaka⁴, Takashi Goto⁵, Michio Hiratani⁶, Yuji Wada⁷

Affiliations

¹ Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan; Department of Neuropsychiatry, University of Fukui, Japan. Electronic address: mak1977019@yahoo.co.jp.
² Department of Pediatrics, University of Fukui, Japan. Electronic address: kawatani@u-fukui.ac.jp.
³ Department of Neuropsychiatry, University of Fukui, Japan. Electronic address: morio@u-fukui.ac.jp.
⁴ Research Center for Child Mental Development, University of Fukui, Japan. Electronic address: hirotaka@u-fukui.ac.jp.
⁵ Department of Neuropsychiatry, University of Fukui, Japan. Electronic address: gotot@u-fukui.ac.jp.
⁶ Hiratani Child Development Clinic, Fukui, Japan. Electronic address: m-hiratani@hiratani-c.jp.
⁷ Department of Neuropsychiatry, University of Fukui, Japan. Electronic address: waday@u-fukui.ac.jp.

PMID: 24434185
DOI: 10.1016/j.braindev.2013.12.005

Abstract

Background: Bipolar disorder (BD) has been linked with the manifestation of catatonia in subjects with autism spectrum disorders (ASD). Idiopathic basal ganglia calcification (IBGC) is characterized by movement disorders and various neuropsychiatric disturbances including mood disorder.

Case: We present a patient with ASD and IBGC who developed catatonia presenting with prominent dystonic feature caused by comorbid BD, which was treated effectively with quetiapine.

Conclusion: In addition to considering the possibility of neurodegenerative disease, careful psychiatric interventions are important to avoid overlooking treatable catatonia associated with BD in cases of ASD presenting with both prominent dystonic features and apparent fluctuation of the mood state.

Keywords: Autism; Basal ganglia calcification; Bipolar disorder; Catatonia; Dystonia; Quetiapine.

Publication types

Case Reports

MeSH terms

Adolescent
Autistic Disorder / complications*
Autistic Disorder / diagnosis
Autistic Disorder / pathology
Basal Ganglia / pathology
Bipolar Disorder / complications*
Bipolar Disorder / diagnosis
Bipolar Disorder / pathology
Brain Diseases / complications*
Brain Diseases / diagnosis
Brain Diseases / pathology
Calcinosis / chemically induced
Calcinosis / complications*
Calcinosis / pathology
Catatonia / complications
Catatonia / diagnosis
Catatonia / drug therapy*
Catatonia / pathology
Diagnosis, Differential
Dibenzothiazepines / therapeutic use*
Humans
Magnetic Resonance Imaging
Male
Quetiapine Fumarate
Tomography, X-Ray Computed

Substances

Dibenzothiazepines
Quetiapine Fumarate