Ho(a)xing autophagy to regulate development

Silvia Campello; Francesco Cecconi

doi:10.1016/j.devcel.2013.12.018

Ho(a)xing autophagy to regulate development

Dev Cell. 2014 Jan 13;28(1):3-4. doi: 10.1016/j.devcel.2013.12.018.

Authors

Silvia Campello¹, Francesco Cecconi²

Affiliations

¹ IRCCS Fondazione Santa Lucia, 00143 Rome, Italy.
² IRCCS Fondazione Santa Lucia, 00143 Rome, Italy; Unit of Cell Stress and Survival, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy. Electronic address: cecconi@cancer.dk.

PMID: 24434134
DOI: 10.1016/j.devcel.2013.12.018

Abstract

In this issue of Developmental Cell, Banreti et al. (2014) demonstrate that canonical autophagy is inhibited in the Drosophila fat body by Hox transcriptional factors. This regulation involves repression of the Atg genes. Programmed developmental autophagy is thus under Hox control and may influence cell fate determination.

Publication types

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MeSH terms

Animals
Autophagy*
Gene Expression Regulation, Developmental*
Homeodomain Proteins / metabolism*

Substances

Homeodomain Proteins