Evaluation of new treatment for incipient enamel demineralization using 45S5 bioglass

A S Bakry; H Takahashi; M Otsuki; J Tagami

doi:10.1016/j.dental.2013.12.002

Evaluation of new treatment for incipient enamel demineralization using 45S5 bioglass

Dent Mater. 2014 Mar;30(3):314-20. doi: 10.1016/j.dental.2013.12.002. Epub 2014 Jan 13.

Authors

A S Bakry¹, H Takahashi², M Otsuki³, J Tagami⁴

Affiliations

¹ Operative Dentistry Department, Faculty of Dentistry, King AbdulAziz University, Jeddah, Saudia Arabia; Conservative Dentistry Department, Faculty of Dentistry, Alexandria University, Egypt; Japan Society for the Promotion of Science, Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address: drahmedbakry@gmail.com.
² Oral Biomaterials Engineering, Department of Oral Materials Sciences and Technology, Course of Oral Health Engineering, School of Health Care Sciences, Faculty of Dentistry, Tokyo Medical and Dental University, 1-5-45Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
³ Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
⁴ Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Global Center of Excellence Program, ICTB at Tokyo Medical and Dental University, Tokyo, Japan.

PMID: 24433821
DOI: 10.1016/j.dental.2013.12.002

Abstract

Bioglass 45S5 is a silica-based bioactive glass capable of depositing a layer of hydroxyl carbonate apatite on the surface of the glass when immersed in body fluids. The present paper studies a new technique for treating early human dental enamel caries lesions by using a paste composed of 45S5 bioglass and phosphoric acid. Artificial caries lesions were induced in enamel flat surfaces by means of a decalcification solution. All specimens were exposed to a brushing-abrasion challenge to test the durability of any newly formed layer resulting from the application of 45S5 bioglass paste. The specimens treated with bioglass paste showed complete coverage with a layer of brushite crystals. The brushing-abrasion challenge did not statistically affect the percentage of enamel coverage with the crystalline layer formed by the application of bioglass (p<0.05). These crystals were converted to hydroxyapatite crystals when stored in artificial saliva for 14 days. The current technique suggests the possibility of restoring incipient enamel erosive lesion with an abrasion durable layer of hydroxyapatite crystals.

Keywords: Bioactive glass; Bioactivity; Brushite; Calcium phosphate coating.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Calcium Phosphates / chemistry
Ceramics / pharmacology*
Coated Materials, Biocompatible
Dental Caries / therapy
Dental Enamel / chemistry*
Durapatite / chemistry
Glass
Humans
In Vitro Techniques
Materials Testing
Molar
Saliva, Artificial
Surface Properties
Time Factors
Tooth Demineralization / therapy*
X-Ray Diffraction

Substances

Calcium Phosphates
Coated Materials, Biocompatible
Saliva, Artificial
bioactive glass 45S5
Durapatite
calcium phosphate, dibasic, dihydrate