Successful prevention of scedosporiosis after lung transplantation in a cystic fibrosis patient by combined local and systemic triazole therapy

Carolin Hartmann; Carsten Müller; Hartmut Weißbrodt; Sebastian Suerbaum; Kathrin Tintelnot; Stefan Stolle; Gesine Hansen; Ludwig Sedlacek

doi:10.1016/j.mmcr.2013.05.001

Successful prevention of scedosporiosis after lung transplantation in a cystic fibrosis patient by combined local and systemic triazole therapy

Med Mycol Case Rep. 2013 May 23:2:116-8. doi: 10.1016/j.mmcr.2013.05.001.

Authors

Carolin Hartmann¹, Carsten Müller¹, Hartmut Weißbrodt², Sebastian Suerbaum², Kathrin Tintelnot³, Stefan Stolle⁴, Gesine Hansen¹, Ludwig Sedlacek²

Affiliations

¹ Department of Pediatrics and Adolescent Medicine, Pediatric Pulmonolgy, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
² Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
³ National Reference Laboratory for Pseudallescheria boydii/Scedosporium spp., Robert Koch-Institut, Berlin, Germany.
⁴ Department of Otolaryngology, Hannover Medical School, Hannover, Germany.

Abstract

A persistent colonization with Scedosporium apiospermum (S. apiospermum) often results in disseminated infection with a high mortality rate in immunosuppressed patients. We present the first case of successful prevention of scedosporiosis in an adolescent female cystic fibrosis patient post double lung transplant, with a combination of local and systemic voriconazole therapy and surgical intervention.

Keywords: Adolescent lung transplantation; Scedosporium apiospermum; Sinusitis; Voriconazole.