Hard metal lung disease diagnosed on a transbronchial lung biopsy following recurrent contact dermatitis

Intern Med. 2014;53(2):139-43. doi: 10.2169/internalmedicine.53.1019. Epub 2012 Mar 1.

Abstract

A 63-year-old man employed in a hard metal manufacturing company for 40 years presented with a chronic dry cough and exertional dyspnea 20 years after the onset of recurrent exanthemas. A chest radiograph revealed bilateral reticular shadows in the upper lung field. Pathological specimens in which tungsten was detected were obtained via a transbronchial lung biopsy. Patch tests were positive for cobalt and other metals. The patient was diagnosed with hard metal lung disease (HMLD) concurrent with contact dermatitis and treated with corticosteroids. This case suggests that allergies to metal may play a role in the onset of HMLD.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Biopsy / methods*
  • Bronchoalveolar Lavage Fluid / cytology
  • Cobalt / adverse effects
  • Cobalt / analysis
  • Dermatitis, Occupational / diagnosis
  • Dermatitis, Occupational / drug therapy
  • Dermatitis, Occupational / etiology*
  • Electron Probe Microanalysis
  • Fibrosis
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lung / chemistry
  • Lung / diagnostic imaging
  • Lung / pathology*
  • Male
  • Metallurgy*
  • Metals, Heavy / adverse effects*
  • Metals, Heavy / analysis
  • Middle Aged
  • Patch Tests
  • Pneumoconiosis / diagnosis
  • Pneumoconiosis / diagnostic imaging
  • Pneumoconiosis / drug therapy
  • Pneumoconiosis / etiology*
  • Pneumoconiosis / pathology
  • Recurrence
  • Smoking / adverse effects
  • Tomography, X-Ray Computed
  • Tungsten / adverse effects
  • Tungsten / analysis

Substances

  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Metals, Heavy
  • Cobalt
  • Tungsten