Antibiotic resistance and detection of the sul2 gene in urinary isolates of Escherichia coli in patients from Brazil

J Infect Dev Ctries. 2014 Jan 15;8(1):39-43. doi: 10.3855/jidc.3380.

Abstract

Introduction: The present study aimed to assess the antibiotic resistance profiles and detect the presence of the sul2 gene in sulfamethoxazole-susceptible and resistant isolates of Escherichia coli obtained from outpatients and inpatients with urinary tract infections.

Methodology: The resistance profiles of 739 strains were assessed and the presence of the sul2 gene in 100 isolates was tested.

Results: The antibiotics with the highest resistance rates were ampicillin (57.4%) and trimethoprim-sulfamethoxazole (44.7%). The presence of the gene sul2 was detected in 66.7% of outpatient samples and 67.9% of inpatient samples.

Conclusions: Our results demonstrate that E. coli isolates exhibit high resistance to various classes of antibiotics, highlighting the need for developing strategies to help in prescribing antibiotics.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • Brazil
  • Carrier Proteins / genetics*
  • Cross-Sectional Studies
  • Drug Resistance, Bacterial*
  • Drug Resistance, Microbial
  • Escherichia coli Infections / microbiology*
  • Humans
  • Microbial Sensitivity Tests
  • Urinary Tract Infections / microbiology*
  • Uropathogenic Escherichia coli / drug effects*
  • Uropathogenic Escherichia coli / genetics*
  • Uropathogenic Escherichia coli / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carrier Proteins
  • Sul2 protein, bacteria