Abstract
Castleman disease is a rare lymphoproliferative disorder that has many presentations ranging from unifocal or multifocal mass lesions to a monoclonal gammopathy. It has features that may overlap with osteosclerotic myeloma or POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome. We report a patient with papilledema, enlarged lymph nodes, and monoclonal IgG, who subsequently developed a polyneuropathy. Biopsy of enlarged mediastinal lymph nodes confirmed the diagnosis of Castleman disease.
MeSH terms
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Adult
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Antineoplastic Agents / therapeutic use
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Castleman Disease / physiopathology*
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Female
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Humans
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Lymph Nodes / pathology
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Magnetic Resonance Imaging
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Optic Nerve / diagnostic imaging
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Optic Nerve / pathology
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Papilledema / diagnosis*
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Papilledema / drug therapy
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Prednisolone / therapeutic use
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Radiography
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Tomography Scanners, X-Ray Computed
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Vincristine / therapeutic use
Substances
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Antineoplastic Agents
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisolone