An organocatalytic asymmetric allylic alkylation allows enantioselective total synthesis of hydroxymetasequirin-A and metasequirin-B tetramethyl ether diacetates

Pu-Sheng Wang; Xiao-Le Zhou; Liu-Zhu Gong

doi:10.1021/ol4037055

An organocatalytic asymmetric allylic alkylation allows enantioselective total synthesis of hydroxymetasequirin-A and metasequirin-B tetramethyl ether diacetates

Org Lett. 2014 Feb 7;16(3):976-9. doi: 10.1021/ol4037055. Epub 2014 Jan 14.

Authors

Pu-Sheng Wang¹, Xiao-Le Zhou, Liu-Zhu Gong

Affiliation

¹ Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei, 230026, China.

PMID: 24423033
DOI: 10.1021/ol4037055

Abstract

The first highly stereoselective organocatalytic intermolecular allylic alkylation of allylic alcohols with 1,3-dicarbonyls has been developed to allow the first enantioselective total synthesis of hydroxymetasequirin-A and metasequirin-B tetramethyl ether diacetates.