High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers

Anthony P Raphael; Clare A Primiero; Lynlee L Lin; Ross Flewell Smith; Philip Dyer; H Peter Soyer; Tarl W Prow

doi:10.1002/adhm.201300517

High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers

Adv Healthc Mater. 2014 Jun;3(6):860-6. doi: 10.1002/adhm.201300517. Epub 2014 Jan 13.

Authors

Anthony P Raphael¹, Clare A Primiero, Lynlee L Lin, Ross Flewell Smith, Philip Dyer, H Peter Soyer, Tarl W Prow

Affiliation

¹ Dermatology Research Centre, The University of Queensland, School of Medicine, Translational Research Institute, Brisbane, Australia, Brisbane, 4102, QLD, Australia.

PMID: 24421280
DOI: 10.1002/adhm.201300517

Abstract

Delivery of therapeutics into skin is hindered by the epidermal barriers. To overcome these barriers for the treatment of skin diseases, a cutaneous delivery method capable of field treatment using silica-elongated microparticles is developed. The microparticles are massaged into the skin using a 3D-printed microtextured applicator resulting in significant field-directed drug delivery enhancement.

Keywords: drug delivery; microneedles; microparticles; silica; skin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Cutaneous
Drug Carriers / chemistry*
Fluorescein / administration & dosage
Fluorescein / chemistry
Healthy Volunteers
Humans
In Vitro Techniques
Microscopy, Confocal
Microspheres*
Silicon Dioxide / chemistry
Skin / metabolism*

Substances

Drug Carriers
Silicon Dioxide
Fluorescein