[Platform for drug discovery targeting HMGB1, AGEs-RAGE response]

Nihon Yakurigaku Zasshi. 2014 Jan;143(1):14-7. doi: 10.1254/fpj.143.14.
[Article in Japanese]
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / metabolism
  • Diabetes Complications / genetics
  • Diabetes Complications / therapy
  • Drug Discovery* / trends
  • Extracellular Signal-Regulated MAP Kinases / metabolism
  • GTP-Binding Proteins / metabolism
  • HMGB1 Protein / physiology*
  • Humans
  • Inflammation / genetics
  • Inflammation / therapy
  • Inflammation Mediators / metabolism
  • Intercellular Adhesion Molecule-1 / metabolism
  • Life Style*
  • Ligands
  • Matrix Metalloproteinases / metabolism
  • Molecular Targeted Therapy*
  • NF-kappa B / metabolism
  • Neoplasms / genetics*
  • Neoplasms / therapy*
  • Phosphorylation
  • Reactive Oxygen Species / metabolism
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic / physiology*

Substances

  • Cytokines
  • HMGB1 Protein
  • Inflammation Mediators
  • Ligands
  • NF-kappa B
  • Reactive Oxygen Species
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic
  • Intercellular Adhesion Molecule-1
  • Extracellular Signal-Regulated MAP Kinases
  • Matrix Metalloproteinases
  • GTP-Binding Proteins