Microchip capillary electrophoresis-electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: an intriguing case

Giovanni Lentini; Solomon Habtemariam

doi:10.1016/j.chroma.2013.12.068

Microchip capillary electrophoresis-electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: an intriguing case

J Chromatogr A. 2014 Jan 31:1327:160. doi: 10.1016/j.chroma.2013.12.068. Epub 2013 Dec 31.

Authors

Giovanni Lentini¹, Solomon Habtemariam²

Affiliations

¹ Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via E. Orabona 4, 70126 Bari, Italy. Electronic address: giovanni.lentini@uniba.it.
² Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UK.

PMID: 24418232
DOI: 10.1016/j.chroma.2013.12.068

Abstract

The strange case of abnormal quantities of unmetabolized paracetamol found in human urine [J. Chromatogr. A 1218 (2011) 739] was examined and an alternative explanation was proposed.

Keywords: Capillary electrophoresis; Glutathione conjugation; Mass spectrometry; Metabolism.

Publication types

Comment

MeSH terms

Acetaminophen / metabolism*
Electrophoresis, Microchip / methods*
Epoxy Compounds / chemistry*
Ethanolamines / metabolism*
Humans
Models, Chemical*
Polymers / chemistry*
Spectrometry, Mass, Electrospray Ionization / methods*
Tramadol / metabolism*

Substances

Epoxy Compounds
Ethanolamines
Polymers
Acetaminophen
Tramadol