Keeping notch target genes off: a CSL corepressor caught in the act

Tilman Borggrefe; Franz Oswald

doi:10.1016/j.str.2013.12.007

Keeping notch target genes off: a CSL corepressor caught in the act

Structure. 2014 Jan 7;22(1):3-5. doi: 10.1016/j.str.2013.12.007.

Authors

Tilman Borggrefe¹, Franz Oswald²

Affiliations

¹ Institute of Biochemistry, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany.
² Center for Internal Medicine, Department of Internal Medicine I, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany. Electronic address: franz.oswald@uni-ulm.de.

PMID: 24411574
DOI: 10.1016/j.str.2013.12.007

Abstract

In this issue of Structure, Collins and colleagues report the structure of the Notch pathway component CSL bound to the corepressor KyoT2. The structure reveals that KyoT2 interacts with CSL in a configuration similar, but not identical to, the Notch RAM domain and provides insights into how CSL switches from an activator to a repressor.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Immunoglobulin J Recombination Signal Sequence-Binding Protein / chemistry*
Intracellular Signaling Peptides and Proteins / chemistry*
LIM Domain Proteins / chemistry*
Muscle Proteins / chemistry*
Receptors, Notch / chemistry*

Substances

Fhl1 protein, mouse
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Intracellular Signaling Peptides and Proteins
LIM Domain Proteins
Muscle Proteins
Rbpj protein, mouse
Receptors, Notch