Fiber bundle endocytoscopy

Biomed Opt Express. 2013 Nov 11;4(12):2781-94. doi: 10.1364/BOE.4.002781. eCollection 2013.

Abstract

Endocytoscopy is an optical biopsy technique which uses a miniaturized camera to capture white light microscopy images through an endoscope. We have developed an alternative design that instead relays images to an external camera via a coherent fiber bundle. In this paper we characterize the device and demonstrate microscopy of porcine tissue ex vivo. One advantage of our approach is the ease with which other bundle-compatible imaging modalities can be deployed simultaneously. We show this by acquiring quasi-simultaneous endocytoscopy and fluorescence confocal endomicroscopy images through a single fiber bundle. This opens up possibilities for multi-modal endomicroscopy, combining white light and fluorescence imaging.

Keywords: (110.0180) Microscopy; (170.2150) Endoscopic imaging.