Macromolecular prodrugs of ribavirin: concerted efforts of the carrier and the drug

Adv Healthc Mater. 2014 Sep;3(9):1404-7. doi: 10.1002/adhm.201300637. Epub 2014 Jan 10.

Abstract

Polymers in tune. Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad-spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching that of the pristine drug and at the same time suppressed the origin of the main side effect of ribavirin.

Keywords: drug delivery; high throughput screening; inflammation; polymers; prodrugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Cell Line
  • Chromatography, Gel
  • Drug Discovery
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Weight
  • Nitric Oxide / analysis
  • Nitric Oxide / metabolism
  • Prodrugs / chemistry*
  • Prodrugs / pharmacology*
  • Ribavirin / chemistry*
  • Ribavirin / pharmacology*

Substances

  • Antiviral Agents
  • Prodrugs
  • Nitric Oxide
  • Ribavirin