Copper-catalyzed Chan-Lam coupling between sulfonyl azides and boronic acids at room temperature

Org Lett. 2014 Jan 17;16(2):338-41. doi: 10.1021/ol403717f. Epub 2014 Jan 9.

Abstract

A mild and efficient method for the synthesis of N-arylsulfonamides in the presence of 10 mol % of CuCl is demonstrated. The reaction proceeds readily at room temperature in an open flask using a variety of sulfonyl azides and boronic acids without any base, ligand, or additive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azides / chemistry*
  • Boronic Acids / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Copper / chemistry*
  • Molecular Structure
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / chemistry*
  • Temperature

Substances

  • Azides
  • Boronic Acids
  • Sulfonamides
  • Copper