Biotechnology and genetic engineering in the new drug development. Part II. Monoclonal antibodies, modern vaccines and gene therapy

Pharmacol Rep. 2013;65(5):1086-101. doi: 10.1016/s1734-1140(13)71467-1.

Abstract

Monoclonal antibodies, modern vaccines and gene therapy have become a major field in modern biotechnology, especially in the area of human health and fascinating developments achieved in the past decades are impressive examples of an interdisciplinary interplay between medicine, biology and engineering. Among the classical products from cells one can find viral vaccines, monoclonal antibodies, and interferons, as well as recombinant therapeutic proteins. Gene therapy opens up challenging new areas. In this review, a definitions of these processes are given and fields of application and products, as well as the future prospects, are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alemtuzumab
  • Animals
  • Antibodies, Monoclonal / biosynthesis*
  • Antibodies, Monoclonal / genetics
  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Humanized / biosynthesis
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / therapeutic use
  • Biotechnology / methods*
  • Cloning, Molecular
  • Diphtheria-Tetanus-Pertussis Vaccine / biosynthesis
  • Diphtheria-Tetanus-Pertussis Vaccine / therapeutic use
  • Gene Transfer Techniques
  • Genetic Engineering*
  • Genetic Therapy*
  • Genetic Vectors
  • Hepatitis B Vaccines / biosynthesis
  • Hepatitis B Vaccines / therapeutic use
  • Humans
  • Hyperlipoproteinemia Type II / genetics
  • Hyperlipoproteinemia Type II / therapy
  • Influenza Vaccines / biosynthesis
  • Influenza Vaccines / therapeutic use
  • Poliovirus Vaccine, Inactivated / biosynthesis
  • Poliovirus Vaccine, Inactivated / therapeutic use
  • RNA Interference
  • Recombinant Proteins / biosynthesis*
  • Recombinant Proteins / genetics
  • Recombinant Proteins / therapeutic use
  • Severe Combined Immunodeficiency / genetics
  • Severe Combined Immunodeficiency / therapy
  • Vaccines, Synthetic / biosynthesis*
  • Vaccines, Synthetic / genetics
  • Vaccines, Synthetic / therapeutic use

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Hepatitis B Vaccines
  • Influenza Vaccines
  • PEDIARIX
  • Poliovirus Vaccine, Inactivated
  • Recombinant Proteins
  • Vaccines, Synthetic
  • Alemtuzumab