Studies of macrophage cellular response to the extracellular hydrogen peroxide by tilapia model

Fish Shellfish Immunol. 2014 Feb;36(2):459-66. doi: 10.1016/j.fsi.2013.12.020. Epub 2014 Jan 4.

Abstract

Reactive oxygen species (ROS) may act as signaling molecules in the physiology responses and the present study aims to investigate the effect of extracellular hydrogen peroxide on macrophages cellular response. The results obtained in the present study showed that the extracellular hydrogen peroxide affectively alter the membrane potential of the cell membrane and ion exchange channels in the cell membrane through intracellular NAD turnover that may lead to an intracellular calcium ion concentration alteration and subsequently induce the downstream signal activation.

Keywords: Cellular physiology; Hydrogen peroxide; Inflammation; Macrophage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Membrane / drug effects
  • Cell Membrane / physiology
  • Dose-Response Relationship, Drug
  • Hydrogen Peroxide / pharmacology*
  • Inflammation
  • Ion Channels / drug effects
  • Ion Channels / physiology
  • Liver / drug effects*
  • Liver / metabolism*
  • Macrophages / drug effects*
  • Macrophages / metabolism
  • Membrane Potentials / drug effects
  • Reactive Oxygen Species / pharmacology*
  • Tilapia / metabolism*

Substances

  • Ion Channels
  • Reactive Oxygen Species
  • Hydrogen Peroxide