Abstract
A practical total synthesis of kainoid MFPA (5) was achieved in only six steps, via a novel Ni-catalyst-mediated asymmetric conjugate addition reaction. Furthermore, a fluorescein-based fluorescent ionotropic glutamate receptor probe 28 was efficiently synthesized from a precursor derived from a synthetic intermediate of 5.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Fluorescein / chemistry*
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / chemistry
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Kainic Acid* / analogs & derivatives
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Kainic Acid* / chemical synthesis
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Kainic Acid* / chemistry
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Molecular Structure
Substances
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Fluorescent Dyes
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Kainic Acid
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Fluorescein