Practical synthesis of kainoids: a new chemical probe precursor and a fluorescent probe

Org Lett. 2014 Jan 17;16(2):564-7. doi: 10.1021/ol403434e. Epub 2014 Jan 7.

Abstract

A practical total synthesis of kainoid MFPA (5) was achieved in only six steps, via a novel Ni-catalyst-mediated asymmetric conjugate addition reaction. Furthermore, a fluorescein-based fluorescent ionotropic glutamate receptor probe 28 was efficiently synthesized from a precursor derived from a synthetic intermediate of 5.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Fluorescein / chemistry*
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Kainic Acid* / analogs & derivatives
  • Kainic Acid* / chemical synthesis
  • Kainic Acid* / chemistry
  • Molecular Structure

Substances

  • Fluorescent Dyes
  • Kainic Acid
  • Fluorescein