miR-92a family and their target genes in tumorigenesis and metastasis

Exp Cell Res. 2014 Apr 15;323(1):1-6. doi: 10.1016/j.yexcr.2013.12.025. Epub 2014 Jan 4.

Abstract

The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized.

Keywords: Regulation; Target genes; Tumors; miR-92a family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis / genetics
  • Cell Transformation, Neoplastic / genetics*
  • Endothelial Cells / cytology
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs / genetics*
  • Neoplasm Invasiveness / genetics*
  • Neoplasm Metastasis / genetics*
  • Neoplasms / genetics*

Substances

  • MIRN92 microRNA, human
  • MicroRNAs