Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release

Int J Pharm. 2014 Mar 10;463(1):22-6. doi: 10.1016/j.ijpharm.2013.12.045. Epub 2014 Jan 4.

Abstract

A novel pH-sensitive controlled release system is proposed by using mussel-inspired polydopamine (PDA) coated mesoporous silica nanoparticles (MSNs) as nanocarriers. MSNs with a large pore diameter are synthesized by using 1,3,5-trimethylbenzene as a pore-expanding agent and are modified with a PDA coating by virtue of oxidative self-polymerization of dopamine in neutral pH. PDA coated MSNs are characterized by FTIR, TEM, N₂ adsorption and XPS techniques. The PDA coating can work as pH-sensitive gatekeepers to control the release of drug molecules from MSNs in response to the pH-stimulus. Doxorubicin (DOX, an anticancer drug) can be released in the acid media and blocked in the neutral media.

Keywords: Controlled release; Drug delivery; Mesoporous silica nanoparticles; Polydopamine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / chemistry
  • Bivalvia
  • Delayed-Action Preparations / chemistry*
  • Doxorubicin / chemistry
  • Drug Carriers / chemistry*
  • Hydrogen-Ion Concentration
  • Indoles / chemistry*
  • Nanoparticles / chemistry*
  • Polymers / chemistry*
  • Porosity
  • Silicon Dioxide / chemistry*

Substances

  • Antibiotics, Antineoplastic
  • Delayed-Action Preparations
  • Drug Carriers
  • Indoles
  • MCM-41
  • Polymers
  • polydopamine
  • Silicon Dioxide
  • Doxorubicin