Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus

Fitoterapia. 2014 Mar:93:98-104. doi: 10.1016/j.fitote.2013.12.021. Epub 2014 Jan 3.

Abstract

Six new shionane-type triterpenes, astershionones A-F (1-6), were obtained from the roots and rhizomes of Aster tataricus. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configuration of 1 was determined by single crystal X-ray diffraction analysis and CD analysis. 3 showed inhibitory activity against HBsAg and HBeAg secretion with IC50 values of 23.0 and 23.1 μM, and cytotoxicity against HepG 2.2.15 cells with a CC50 value of 170.5 μM. 3 also exhibited inhibitory activity against HBV DNA replication with an IC50 value of 22.4 μM.

Keywords: Anti-HBV; Aster tataricus; Astershionones A–F; Lamivudine (PubChem CID: 60825); Shionane-type triterpenes; Shionone (PubChem CID: 12315507).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Aster Plant / chemistry*
  • DNA Replication / drug effects
  • Hep G2 Cells
  • Hepatitis B virus / drug effects*
  • Humans
  • Molecular Structure
  • Plants, Medicinal / chemistry
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Antiviral Agents
  • Triterpenes
  • shionone