Trinorditerpenes from the roots of Flueggea virosa

Chih-Hua Chao; Ju-Chien Cheng; Tsong-Long Hwang; De-Yang Shen; Tian-Shung Wu

doi:10.1016/j.bmcl.2013.12.051

Trinorditerpenes from the roots of Flueggea virosa

Bioorg Med Chem Lett. 2014 Jan 15;24(2):447-9. doi: 10.1016/j.bmcl.2013.12.051. Epub 2013 Dec 20.

Authors

Chih-Hua Chao¹, Ju-Chien Cheng², Tsong-Long Hwang³, De-Yang Shen⁴, Tian-Shung Wu⁵

Affiliations

¹ School of Pharmacy, China Medical University, Taichung 404, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. Electronic address: chaochihhua@hotmail.com.
² Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan.
³ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
⁴ Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
⁵ Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: tswu@mail.ncku.edu.tw.

PMID: 24388689
DOI: 10.1016/j.bmcl.2013.12.051

Abstract

Two trinorditerpenes, flueggrenes A and B (1 and 2), have been isolated from the roots of Flueggea virosa. Their structures were established by extensive analyses of spectroscopic data. The isolates were evaluated for anti-HCV activity, as well as the inhibition of superoxide anion generation and elastase release in response to FMLP/cytochalasin B.

Keywords: Anti-HCV; Flueggea virosa; Flueggrene A; Flueggrene B.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology
Euphorbiaceae*
Humans
Neutrophils / drug effects
Neutrophils / metabolism
Plant Extracts / chemistry*
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plant Roots*

Substances

Diterpenes
Plant Extracts