Differential expression of monocyte surface markers among TB patients with diabetes co-morbidity

Tuberculosis (Edinb). 2013 Dec;93 Suppl(0):S78-82. doi: 10.1016/S1472-9792(13)70015-5.

Abstract

The expression of monocyte surface markers was compared between tuberculosis patients with and without type 2 diabetes (DM2). DM2 was associated with increased CCR2 expression, which may restrain monocyte traffic to the lung. Other host factors associated with baseline monocyte changes were older age (associated with lower CD11b) and obesity (associated with higher RAGE). Given that DM2 patients are more likely to be older and obese, their monocytes are predicted to be altered in function in ways that affect their interaction with Mycobacterium tuberculosis.

Keywords: CCR2; CD11b; Diabetes; Innate immunity; Monocyte; RAGE; Tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aging / metabolism
  • Biomarkers / metabolism
  • Body Mass Index
  • CD11b Antigen / metabolism
  • Cell Adhesion
  • Comorbidity
  • Diabetes Mellitus, Type 2 / immunology
  • Diabetes Mellitus, Type 2 / metabolism*
  • Disease Susceptibility
  • Female
  • Host-Pathogen Interactions
  • Humans
  • Male
  • Monocytes / metabolism*
  • Mycobacterium tuberculosis / physiology*
  • Prognosis
  • Receptor for Advanced Glycation End Products / metabolism
  • Receptors, CCR2 / metabolism
  • Receptors, Cell Surface / metabolism*
  • Tuberculosis / immunology
  • Tuberculosis / metabolism*

Substances

  • Biomarkers
  • CCR2 protein, human
  • CD11b Antigen
  • ITGAM protein, human
  • Receptor for Advanced Glycation End Products
  • Receptors, CCR2
  • Receptors, Cell Surface