Febuxostat contributes to improvement of endothelial dysfunction in an experimental model of streptozocin-induced diabetic rats

Int J Cardiol. 2014 Feb 15;171(3):e110-2. doi: 10.1016/j.ijcard.2013.12.023. Epub 2013 Dec 22.

Authors

Seung Joon Hwang¹, Kyung Hye Lee¹, Hyun Hee Jang¹, So Ra Lee¹, Jong Shin Woo¹, Hong Ju Lee², Kyung Hwan Jung², Weon Kim³

Affiliations

¹ Department of Cardiology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Republic of Korea.
² Department of Nephrology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Republic of Korea.
³ Department of Cardiology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Republic of Korea. Electronic address: mylovwkw@hanmail.net.

PMID: 24388547
DOI: 10.1016/j.ijcard.2013.12.023

No abstract available

Keywords: Endothelial dysfunction; Nitric oxide; Xanthine oxidase.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Diabetes Mellitus, Experimental / drug therapy*
Diabetes Mellitus, Experimental / metabolism
Diabetes Mellitus, Experimental / physiopathology*
Endothelium, Vascular / drug effects*
Endothelium, Vascular / metabolism
Endothelium, Vascular / physiopathology*
Febuxostat
Male
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species / metabolism
Thiazoles / pharmacology
Thiazoles / therapeutic use*

Substances

Reactive Oxygen Species
Thiazoles
Febuxostat