Entrapment exploited

Jos A G van Strijp; Suzan H M Rooijakkers

doi:10.1016/j.tim.2013.12.010

Entrapment exploited

Trends Microbiol. 2014 Feb;22(2):55-7. doi: 10.1016/j.tim.2013.12.010. Epub 2013 Dec 31.

Authors

Jos A G van Strijp¹, Suzan H M Rooijakkers²

Affiliations

¹ Medical Microbiology, UMC Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands. Electronic address: j.vanstrijp@umcutrecht.nl.
² Medical Microbiology, UMC Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands.

PMID: 24387831
DOI: 10.1016/j.tim.2013.12.010

Abstract

In their recent paper in Science, Thammavongsa et al. demonstrate how Staphylococcus aureus degrades the DNA of neutrophil extracellular traps (NETs) into 2'-deoxy-adenosine, which causes incoming macrophages to go into apoptosis, thereby increasing the chance for the bacterium to survive in an abscess.

Publication types

Comment

MeSH terms

Animals
Apoptosis / immunology*
Deoxyadenosines / metabolism*
Host-Pathogen Interactions / immunology*
Humans
Neutrophils / immunology*
Neutrophils / microbiology*
Staphylococcal Infections / immunology*
Staphylococcus aureus / pathogenicity*

Substances

Deoxyadenosines