Through arrangement and analysis of domestic and overseas literature about effect of acupoint, it is found that acupoint is an amplifier of acupuncture effect, which could present feature of weak-stimulation and strong-response for acupuncture stimulation. It is also thought that factors of the amplification effect are complicated, it is closely related to the local specificity of acupoint (including more nerves, more blood vessels, more mast cells, more Ca2+ and more energy metabolism) and circulation route of meridians, indicating the amplification effect works through local feeling (local specificity of acupoint) into the distal end (circulation and distribution route of meridian system.