Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles

G Wang; R M de Kruijff; A Rol; L Thijssen; E Mendes; A Morgenstern; F Bruchertseifer; M C A Stuart; H T Wolterbeek; A G Denkova

doi:10.1016/j.apradiso.2013.12.008

Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles

Appl Radiat Isot. 2014 Feb:85:45-53. doi: 10.1016/j.apradiso.2013.12.008. Epub 2013 Dec 15.

Authors

G Wang¹, R M de Kruijff¹, A Rol¹, L Thijssen¹, E Mendes², A Morgenstern³, F Bruchertseifer³, M C A Stuart⁴, H T Wolterbeek¹, A G Denkova⁵

Affiliations

¹ Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.
² Department of Chemical Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft, The Netherlands.
³ European Commission, Joint Research Centre, Institute for Transuranium Elements, PO Box 2340, 76125 Karlsruhe, Germany.
⁴ Electron Microscopy Group, Groningen, Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
⁵ Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands. Electronic address: a.g.denkova@tudelft.nl.

PMID: 24374072
DOI: 10.1016/j.apradiso.2013.12.008

Abstract

Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of (221)Fr and (213)Bi when encapsulating (225)Ac.

Keywords: Alpha radionuclide therapy; Polymersomes; Recoil retention.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinium / administration & dosage*
Actinium / chemistry*
Actinium / pharmacokinetics
Alpha Particles / therapeutic use
Biological Transport, Active
Bismuth / administration & dosage
Bismuth / chemistry
Bismuth / pharmacokinetics
Butadienes / chemistry
Drug Compounding
Francium / chemistry
HeLa Cells
Humans
Lead Radioisotopes / chemistry
Monte Carlo Method
Particle Size
Polyethylene / chemistry
Radioisotopes / chemistry
Radiopharmaceuticals / administration & dosage
Radiopharmaceuticals / chemistry
Radiopharmaceuticals / pharmacokinetics

Substances

Butadienes
Lead Radioisotopes
Radioisotopes
Radiopharmaceuticals
poly(1,2-butadiene-b-ethylene oxide)
Francium
Polyethylene
Actinium
Bismuth