Myocardin and smooth muscle differentiation

Arch Biochem Biophys. 2014 Feb 1:543:48-56. doi: 10.1016/j.abb.2013.12.015. Epub 2013 Dec 25.

Abstract

Myocardin (MYOCD), a co-transcriptional activator of serum response factor (SRF), stimulates the expression of smooth muscle (SM) genes and inhibits the cell cycle. In addition to its roles in the development, MYOCD may be critically involved in the pathogenesis of proliferative vascular diseases. This review mainly focuses on how MYOCD activity is regulated and how it inhibits cell proliferation.

Keywords: Myocardin; Smooth muscle cell proliferation; Smooth muscle differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Gene Expression Regulation
  • Humans
  • Models, Biological
  • Muscle Contraction
  • Muscle, Smooth / cytology*
  • Muscle, Smooth / metabolism
  • Muscle, Smooth / physiology
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / deficiency
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Trans-Activators / chemistry
  • Trans-Activators / deficiency
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*

Substances

  • Nuclear Proteins
  • Trans-Activators
  • myocardin