G protein-coupled receptors as regulators of glucose homeostasis and therapeutic targets for diabetes mellitus

Prog Mol Biol Transl Sci. 2014:121:1-21. doi: 10.1016/B978-0-12-800101-1.00001-6.

Abstract

As critical regulators of almost all physiological processes in the body, G protein-coupled receptors (GPCRs) are important regulators of glucose homeostasis. Some of the newer drugs for treating diabetes mellitus or in development are also targeting GPCRs. This chapter provides a summary of some of the GPCRs that have been shown to be involved in regulating glucose homeostasis.

Keywords: G protein-coupled receptor; Glucose homeostasis; Incretin; Neuropeptides; Pancreatic peptide.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / metabolism*
  • Diabetes Mellitus / therapy*
  • Glucose / metabolism*
  • Homeostasis*
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Molecular Targeted Therapy*
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • Insulin
  • Receptors, G-Protein-Coupled
  • Glucose